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2024 Publications

• Badmus OO, da Silva AA, Li X, Taylor LC, Greer JR, Wasson AR, McGowan KE, Patel PR, Stec DE. Cardiac lipotoxicity and fibrosis underlie impaired contractility in a mouse model of metabolic dysfunction-associated steatotic liver disease. FASEB Bioadv. 2024 Mar 28;6(5):131-142. doi: 10.1096/fba.2023-00139. PMID: 38706754; PMCID: PMC11069051.
• Bhattarai U, Xu R, He X, Pan L, Niu Z, Wang D, Zeng H, Chen JX, Clemmer JS, Chen Y. High selenium diet attenuates pressure overload-induced cardiopulmonary oxidative stress, inflammation, and heart failure. Redox Biol. 2024 Oct;76:103325. doi: 10.1016/j.redox.2024.103325. Epub 2024 Aug 22. PMID: 39197316; PMCID: PMC11399737.
• Cantrell AC, Besanson J, Williams Q, Hoang N, Edwards K, Bishop GR, Chen Y, Zeng H, Chen JX. Ferrostatin-1 specifically targets mitochondrial iron-sulfur clusters and aconitase to improve cardiac function in Sirtuin 3 cardiomyocyte knockout mice. J Mol Cell Cardiol. 2024 Jul;192:36-47. doi: 10.1016/j.yjmcc.2024.05.003. Epub 2024 May 9. PMID: 38734062; PMCID: PMC11164624.
• Chen JX, Zhang J, Chen Y, Zeng H. Knockout of Sirtuin 3 in endothelial cells impairs endothelial-dependent relaxation and myogenic response in mice. Physiol Rep. 2024 Oct;12(20):e70060. doi: 10.14814/phy2.70060. PMID: 39425510; PMCID: PMC11489619.
• do Carmo JM, Hall JE, Furukawa LNS, Woronik V, Dai X, Ladnier E, Wang Z, Omoto ACM, Mouton A, Li X, Luna-Suarez EM, da Silva AA. Chronic central nervous system leptin administration attenuates kidney dysfunction and injury in a model of ischemia/reperfusion-induced acute kidney injury. Am J Physiol Renal Physiol. 2024 Oct 3. doi: 10.1152/ajprenal.00158.2024. Epub ahead of print. PMID: 39361725.
• do Carmo JM, Hall JE, Dai X, Aitken N, Larson K, Luna-Suarez EM, Wang Z, Omoto ACM, Mouton A, Li X, Furukawa LNS, Woronik V, da Silva AA. Parental obesity predisposes offspring to kidney dysfunction and increased susceptibility to ischemia/reperfusion injury in a sex-dependent manner. Am J Physiol Renal Physiol. 2024 Mar 21. doi: 10.1152/ajprenal.00294.2023. Epub ahead of print. PMID: 38511219.
• Eddy AC, Rajakumar A, Spradley FT, Granger JP, Rana S. Luteolin prevents TNF-α-induced NF-κB activation and ROS production in cultured human placental explants and endothelial cells. Placenta. 2024 Jan;145:65-71. doi: 10.1016/j.placenta.2023.12.004. Epub 2023 Dec 8. PMID: 38096686.
• Falkner B, Alexander BT, Nuyt AM, South AM, Ingelfinger J. Cardiovascular Health Starts in the Womb. Hypertension. 2024 Oct;81(10):2016-2026. doi: 10.1161/HYPERTENSIONAHA.124.21359. Epub 2024 Jul 29. PMID: 39069922; PMCID: PMC11410535.
• Fatmi MK, Rouhi N, Lozonschi L, Li J. Cardiac metabolism in the elderly: effects and consequences. Aging (Albany NY). 2024 Aug 19;16(16):11773-11775. doi: 10.18632/aging.206071. Epub 2024 Aug 19. PMID: 39167437; PMCID: PMC11386932.
• Fatmi MK, Wang H, Slotabec L, Wen C, Seale B, Zhao B, Li J. Single-Cell RNA-seq reveals transcriptomic modulation of Alzheimer's disease by activated protein C. Aging (Albany NY). 2024 Feb 21;16(4):3137-3159. doi: 10.18632/aging.205624. Epub 2024 Feb 21. PMID: 38385967; PMCID: PMC10929801.
• Hall ME, Mace HP, Hall JE. Bariatric Surgery for Obesity Hypertension: A gateway for durable blood pressure control. J Am Coll Cardiol. 2024 Feb 13;83(6):649-651. doi: 10.1016/j.jacc.2023.11.033. PMID: 38325989.
• Hamby M, Stec DE, Hildebrandt E, Stec DF, Drummond HA. Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome. Front Endocrinol (Lausanne). 2024 Aug 19;15:1449344. doi: 10.3389/fendo.2024.1449344. PMID: 39224121; PMCID: PMC11366616.
• He X, Williams QA, Cantrell AC, Besanson J, Zeng H, Chen JX. TIGAR Deficiency Blunts Angiotensin-II-Induced Cardiac Hypertrophy in Mice. Int J Mol Sci. 2024 Feb 19;25(4):2433. doi: 10.3390/ijms25042433. PMID: 38397106; PMCID: PMC10889085.
• He X, Cantrell AC, Williams QA, Gu W, Chen Y, Chen JX, Zeng H. p53 Acetylation exerts critical roles in pressure overload-induced coronary microvascular dysfunction and heart failure in mice. Arterioscler Thromb Vasc Biol. 2024 Feb 8. doi: 10.1161/ATVBAHA.123.319601. Epub ahead of print. PMID: 38328937.
• Kipp ZA, Badmus OO, Stec DE, Hall B, Hinds TD Jr. Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome. Metabolism. 2024 Nov 22;163:156081. doi: 10.1016/j.metabol.2024.156081. Epub ahead of print. PMID: 39580049.
• Koubar SH, Garcia-Rivera A, Mohamed MMB, Hall JE, Hall ME, Hassanein M. Underlying mechanisms and treatment of hypertension in glomerular diseases. Curr Hypertens Rep. 2024 Mar;26(3):119-130. doi: 10.1007/s11906-023-01287-9. Epub 2023 Nov 20. PMID: 37982994.
• Liu B, Zeng H, Su H, Williams QA, Besanson J, Chen Y, Chen JX. Endothelial Cell-Specific Prolyl Hydroxylase-2 Deficiency Augments Angiotensin II-Induced Arterial Stiffness and Cardiac Pericyte Recruitment in Mice. J Am Heart Assoc. 2024 Aug 20;13(16):e035769. doi: 10.1161/JAHA.124.035769. Epub 2024 Jul 26. PMID: 39056332.
• Mouton AJ, Aitken NM, Morato JG, do Carmo JM, da Silva AA, Omoto AC, Li X, Wang Z, Schrimpe-Rutledge AC, Codreanu SG, Sherrod SD, McLean JA, Stanford JK, Brown JA, Hall JE. Glutamine metabolism improves left ventricular function but not macrophage-mediated inflammation following myocardial infarction. Am J Physiol Cell Physiol. 2024 Jul 9. doi: 10.1152/ajpcell.00272.2024. Epub ahead of print. PMID: 38981605.
• Omoto ACM, Earl CC, Richards AM, Annamalai K, Nelson B, Hall JE, Goergen CJ, da Silva AA. 4D ultrasound-based strain assessment of cardiac dysfunction in male rats with reperfused and nonreperfused myocardial infarction. Physiol Rep. 2024 Jul;12(14):e16159. doi: 10.14814/phy2.16159. PMID: 39039717; PMCID: PMC11263132.
• Omoto ACM, do Carmo JM, da Silva AA, Hall JE, Mouton AJ. Immunometabolism, extracellular vesicles and cardiac injury. Front Endocrinol (Lausanne). 2024 Jan 8;14:1331284. doi: 10.3389/fendo.2023.1331284. PMID: 38260141; PMCID: PMC10800986.
• Pal P, Medina A, Chowdhury S, Cates CA, Bollavarapu R, Person JM, McIntyre B, Speed JS, Janorkar AV. Influence of the Tissue Collection Procedure on the Adipogenic Differentiation of Human Stem Cells: Ischemic versus Well-Vascularized Adipose Tissue. Biomedicines. 2024 May 1;12(5):997. doi: 10.3390/biomedicines12050997. PMID: 38790959; PMCID: PMC11117639.
• Pal P, Maranon RO, Rivera Gonzales OJ, Speed JS, Janorkar AV. Sexual Dimorphism's impact on adipogenesis: A three-dimensional in vitro model treated with 17β-estradiol and testosterone. Mol Cell Endocrinol. 2024 Aug 1;589:112249. doi: 10.1016/j.mce.2024.112249. Epub 2024 Apr 9. PMID: 38604550; PMCID: PMC11144096.
• Pan L, He X, Xu R, Bhattarai U, Niu Z, do Carmo J, Sun Y, Zeng H, Clemmer JS, Chen JX, Chen Y. Endothelial specific prolyl hydroxylase domain-containing protein 2 deficiency attenuates aging-related obesity and exercise intolerance. Geroscience. 2024 Mar 11. doi: 10.1007/s11357-024-01108-0. Epub ahead of print. PMID: 38462569.
• Rezq S, Huffman AM, Basnet J, Alsemeh AE, do Carmo JM, Yanes Cardozo LL, Romero DG. MicroRNA-21 modulates brown adipose tissue adipogenesis and thermogenesis in a mouse model of polycystic ovary syndrome. Biol Sex Differ. 2024 Jul 10;15(1):53. doi: 10.1186/s13293-024-00630-2. PMID: 38987854; PMCID: PMC11238487.
• Rivera-Gonzalez O, Mills MF, Konadu BD, Wilson NA, Murphy HA, Newberry MK, Hyndman KA, Garrett MR, Webb DJ, Speed JS. Adipocyte endothelin B receptor activation inhibits adiponectin production and causes insulin resistance in obese mice. Acta Physiol (Oxf). 2024 Aug 3:e14214. doi: 10.1111/apha.14214. Epub ahead of print. PMID: 39096077.
• Ryan MJ, Clemmer JS, Mathew RO, Faulkner JL, Taylor EB, Abais-Battad JM, Hollis F, Sullivan JC. Revisiting sex as a biological variable in hypertension research. J Clin Invest. 2024 Sep 3;134(17):e180078. doi: 10.1172/JCI180078. PMID: 39225093; PMCID: PMC11364402.
• Seale B, Slotabec L, Nguyen JD, Wang H, Patterson C, Filho F, Rouhi N, Adenawoola MI, Li J. Sestrin2 serves as a scaffold protein to maintain cardiac energy and metabolic homeostasis during pathological stress. FASEB J. 2024 Oct 31;38(20):e70106. doi: 10.1096/fj.202401404R. PMID: 39404019.
• Slotabec Lily, Wang Hao, Seale Blaise, Wen Changhong, Filho Fernando, Li Ji. Cardiac Diastolic Dysfunction by Cigarette Smoking is Associated with Mitochondrial Integrity in the Heart. FASEB J. 2024 Jul 31;38(14):e23826.doi: 10.1096/fj.202400858R.
• Slotabec L, Seale B, Wang H, Wen C, Filho F, Rouhi N, Adenawoola MI, Li J. Platelets at the intersection of inflammation and coagulation in the APC-mediated response to myocardial ischemia/reperfusion injury. FASEB J. 2024 Aug 31;38(16):e23890. doi: 10.1096/fj.202401128R. PMID: 39143722.
• Smith AM, Taylor EB, Brooks RJ, Dos Santos E Santos C, Grayson BE. Cerebral and Peripheral Immune Cell Changes following Rodent Juvenile Traumatic Brain Injury. Brain Sci. 2024 Apr 19;14(4):398. doi: 10.3390/brainsci14040398. PMID: 38672047; PMCID: PMC11048136.
• van Kammen CM, Taal SEL, Wever KE, Granger JP, Lely AT, Terstappen F. Reduced uterine perfusion pressure as a model for preeclampsia and fetal growth restriction in murine: a systematic review and meta-analysis. Am J Physiol Heart Circ Physiol. 2024 Jul 1;327(1):H89-H107. doi: 10.1152/ajpheart.00056.2024. Epub 2024 May 17. PMID: 38758122.
• Wang D, Weng X, Yue W, Shang L, Wei Y, Clemmer JS, Xu Y, Chen Y. CD8 T cells promote heart failure progression in mice with preexisting left ventricular dysfunction. Front Immunol. 2024 Sep 11;15:1472133. doi: 10.3389/fimmu.2024.1472133. PMID: 39324134; PMCID: PMC11422781.
• Wang H, Slotabec L, Didik S, Li Z, Leng L, Zhao B, Bucala R, Li J. A small molecule macrophage migration inhibitory factor agonist ameliorates age-related myocardial intolerance to ischemia-reperfusion insults via metabolic regulation. Metabolism. 2024 Jan 15;153:155792. doi: 10.1016/j.metabol.2024.155792. Epub ahead of print. PMID: 38232801.
• Wang H, Rouhi N, Slotabec LA, Seale BC, Wen C, Filho F, Adenawoola MI, Li J. Myeloid Cells in Myocardial Ischemic Injury: The Role of the Macrophage Migration Inhibitory Factor. Life (Basel). 2024 Aug 5;14(8):981. doi: 10.3390/life14080981. PMID: 39202723; PMCID: PMC11355293.
• Wang Z, Fu Y, da Silva AA, do Carmo JM, Mouton A, Omoto ACM, Li X, Sears J, Hall JE. Mitochondria-derived reactive oxygen species contribute to synergistic interaction of diabetes and hypertension in causing chronic kidney injury. Am J Physiol Renal Physiol. 2024 Jan 25. doi: 10.1152/ajprenal.00320.2023. Epub ahead of print. PMID: 38269408.
• Warrington JP, Collins HE, Davidge ST, do Carmo JM, Goulopoulou S, Intapad S, Loria AS, Sones JL, Wold LE, Zinkhan EK, Alexander BT. Guidelines for in vivo models of developmental programming of cardiovascular disease risk. Am J Physiol Heart Circ Physiol. 2024 Jul 1;327(1):H221-H241. doi: 10.1152/ajpheart.00060.2024. Epub 2024 May 31. PMID: 38819382.
• Wasson R, Fleming AB, McLin J, Hildebrandt E, Drummond HA. Bone marrow monocytes and macrophages from mice lacking βENaC and ASIC2 have a reduced chemotactic migration response and polarization. Physiol Rep. 2024 Jul;12(14):e16139. doi: 10.14814/phy2.16139. PMID: 39016176; PMCID: PMC11253027.
• Yuan J, Yu Z, Zhang P, Luo K, Xu Y, Lan T, Zhang M, Chen Y, Lu Z. DDAH1 recruits peroxiredoxin 1 and sulfiredoxin 1 to preserve its activity and regulate intracellular redox homeostasis. Redox Biol. 2024 Apr;70:103080. doi: 10.1016/j.redox.2024.103080. Epub 2024 Feb 8. PMID: 38354630; PMCID: PMC10876909.